West Virginia was 0-8 on the road against Connecticut before Monday night's contest. The Mountaineers are now 0-9.
Jeremy Lamb scored 25 points, Andre Drummond scored 20 and the Huskies overcame a 10 point second-half deficit to earn a 64-57 comeback victory over West Virginia.
The visitors led 46-36 with 11 minutes left to play, but UConn ended the game on a 28-11 run.
"The truth is, when you got a player like Jeremy Lamb, you ride him, and they did," West Virginia head coach Bob Huggins said on his postgame radio show with the Mountaineer Sports Network
"It's frustrating," Huggins said. "I thought we could come in here and win. We just break down."
The Big East Conference is known for its high-quality teams. Playing just two days after defeating ninth-ranked Georgetown, West Virginia was given little time to prepare for the 16th-ranked Huskies.
West Virginia shot just 27 percent from the floor in the second half.
"As much as we talk to them and scream at them, we just don't run an offense," Huggins said
Connecticut made its first four shots, with all of them coming in the paint.
"They are really, really talented," Huggins said. "They probably have two of the top picks in the (NBA) draft."
Despite the Huskies' success on the inside, the Mountaineers were able to keep the game close due to sharp shooting from senior guard Truck Bryant early in the game.
However, Bryant picked up his second foul and was forced to sit out the remainder of the first half.
Senior forward Kevin Jones hit three three-pointers to anchor the load with Bryant on the bench.
Jones' 13 first-half points allowed the visitors to take a 33-28 lead into the locker room.
The Mountaineers held a 35-19 shot advantage at the half, while forcing nine turnovers.
West Virginia missed its first eight shots of the second half, but was still able to maintain its lead behind more strong play from Jones.
Junior forward Deniz Kilicli made a hook shot to give the Mountaineers a 46-36 advantage, their largest of the game, with less than 12 minutes left to play.
Connecticut responded with a 12-2 run and, suddenly, the game was tied 48-48.
"We just didn't run any offense," Huggins said. "Those two freshmen guards just aren't experienced and tough enough."
The Huskies had grabbed all the momentum and eventually grabbed the lead.
But, West Virginia didn't quit. The Mountaineers tied the game at 55 apiece with three minutes remaining.
However, Connecticut made enough plays down the stretch to seal the win.
"We can keep making excuses for them, but that ain't going to get us anywhere," Huggins said.
Jones had 22 points in a losing effort.