Tray Woodall scored 24 points and Pittsburgh quieted the Coliseum crowd of 13,032 with a 72-66 victory on Monday night.
Woodall scored 16 points in the first half and the Panthers were able to hold off a late push by the Mountaineers.
West Virginia has now lost three straight games for the first time since 2007.
"It's just hard losing three games in a row. I'm not accustomed to losing," said West Virginia forward Kevin Jones. "It's tough to bear as a competitor. Sometimes, when we lose, I can't even sleep."
Pittsburgh extended its winning streak to three straight games.
"I'm going to schedule a team meeting," Bryant said. "We need to win some games, and we got to win them fast."
The Mountaineers used sharp outside shooting from freshman guard Jabarie Hinds to jump out to a 17-9 first-half lead.
But, West Virginia would go the next 7:20 without a made field goal. Jones got an offensive rebound and layup to tie the game at 23-23 late in the first half.
Pitt's Tray Woodall had 16 points in the first half to lead all scorers and the Panthers held a 33-29 advantage at the half.
Pittsburgh shot 50 percent from the floor in the first 20 minutes and forced seven Mountaineer turnovers.
The Panthers continued to extend their lead early in the second half. Pitt scored eight of the first 10 points and had its largest lead of the game, 41-31.
West Virginia was able to chip away at the Panther lead and only trailed 48-43 with 12 minutes remaining.
Jones and the Mountaineers continued to chip away at the deficit later in the half.
Hinds made a layup in transition to bring the home team within two, 54-52 – the closest West Virginia had been to the lead in the second half.
However, the Panthers would yet again respond to the run and held a 63-56 advantage with 3:35 left to play.
"We haven't played with any consistency all year," said West Virginia head coach Bob Huggins.
A late push by the Mountaineers fell short, and the Panthers won their third straight game in Big East Conference play.
"We have to get our confidence back up," Hinds said. "We just have to play as a team."
Jones finished with 21 points and 13 rebounds. It was his eighth straight game of at least 20 points.
"Whether I put up 20 (points) or 10, I just want the team to win," Jones said. "It doesn't matter about the numbers to me. It's just not a satisfying feeling after a loss, no matter how good or bad you play."
Truck Bryant chipped in 14 points, while Deniz Kilicli and Jabarie Hinds added 12 and 10 points, respectively.
Kevin Noreen left the game in the first half with an injury. Huggins said after the game that Noreen had suffered a broken ankle.