Louisville erased a nine-point second-half deficit to defeat West Virginia 77-74 in come-from-behind fashion on Saturday afternoon at the Coliseum.
"We didn't do the things that we have to do," said West Virginia head coach Bob Huggins. "Our margin for error is not very great."
For the second-consecutive game, the Mountaineers held a lead late in the second half but were unable to close out the win.
"We just can't get over the hump," said West Virginia senior guard Truck Bryant. "The last two (games) have been down to the wire. We got to get over the hump. This would have been a great quality win for us but we didn't get it. It's in the past. We have to look forward to the next game."
West Virginia has now lost five of its last six games.
"It feels really bad especially because you want to win so bad for the fans that came out here to support you," said West Virginia senior forward Kevin Jones. "You just definitely want to win for the state, as well, so it's kind of frustrating."
Sharp Shooting from Louisville's Kyle Kuric helped the Cardinals quiet the Coliseum crowd early. But, the Mountaineers would respond.
After being held scoreless in a loss Notre Dame on Wednesday, Bryant provided an offensive spark in the first half.
He scored six early points to help the Mountaineers grab an early advantage.
West Virginia then used a 12-0 run to take a 30-20 lead with eight minutes remaining in the first half.
The home team would lead by as many as 13 in the first half before the Cardinals closed on a 10-4 run to only trail 44-37 at the half.
Junior forward Deniz Kilicli led all scorers with 15 first-half points, but picked up his third foul just before the half ended.
Mountaineers senior forward Kevin Jones hit back-to-back three-pointers to begin the second half, and West Virginia led 53-42.
West Virginia was forced to play without Kilicli for the first eight minutes after the half and Louisville was able to cut the deficit to five.
Louisville's full-court press caused some problems, as the Cardinals only trailed 63-58 midway through the second half after a steal and layup.
"We just panicked for no reason. It wasn't really what they did as much of what we didn't do," Jones said.
"It was a lot of pressure, but I think we just didn't meet the ball," Bryant said.
Louisville continued to chip away at the lead and only trailed by three when Kilicli picked up his fourth foul with less than seven minutes remaining.
West Virginia led by seven with 5:52 left before an 11-0 run gave the Cardinals a 75-71 advantage.
The Mountaineers trailed by three with 5.5 seconds remaining when a desperate heave by Bryant fell short.
Jones, Kilicli and Bryant scored 22, 17 and 13 points, respectively.
Kuric led five Cardinals in double figures.